We use the Northern Hemisphere Tree-Ring Network Development (NTREND) tree-ring database to examine the effects of using a small, highly-sensitive proxy network for paleotemperature data assimilation over the last millennium. We first evaluate our methods using pseudo-proxy experiments. These indicate that spatial assimilations using this network are skillful in the extratropical Northern Hemisphere and improve on previous NTREND reconstructions based on Point-by-Point regression. We also find our method is sensitive to climate model biases when the number of sites becomes small. Based on these experiments, we then assimilate the real NTREND network. To quantify model prior uncertainty, we produce 10 separate reconstructions, each assimilating a different climate model. These reconstructions are most dissimilar prior to 1100 CE, when the network becomes sparse, but show greater consistency as the network grows. Temporal variability is also underestimated before 1100 CE. Our assimilation method produces spatial uncertainty estimates and these identify treeline North America and eastern Siberia as regions that would most benefit from development of new millennial-length temperature-sensitive tree-ring records. We compare our multi-model mean reconstruction to five existing paleo-temperature products to examine the range of reconstructed responses to radiative forcing. We find substantial differences in the spatial patterns and magnitudes of reconstructed responses to volcanic eruptions and in the transition between the Medieval epoch and Little Ice Age. These extant uncertainties call for the development of a paleoclimate reconstruction intercomparison framework for systematically examining the consequences of proxy network composition and reconstruction methodology and for continued expansion of tree-ring proxy networks.